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phenobarbital boosts toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers may possibly boost the metabolism of ifosfamide to its Energetic alkylating metabolites.No dosage adjustment for ondansetron is suggested for sufferers on these medication.Minimal (one)phenobarbital will lessen th